Advanced genetic characterization of your genetically engineered models
Thursday 30 September 2021 - 4 PM CET / 10 AM ET
Random transgenesis, resulting from pronuclear injection to generate transgenic strains, can potentially disrupt key endogenous genes. As such, identifying the exact genomic position(s) of a transgene insertion site will allow better genotype-phenotype correlation, enhance predictability of transgene segregation during breeding and intercrossing or even facilitate the determination of zygosity via genotyping. Similarly, genome editing tools such as CRISPR-Cas9 can result in undesired on-target sequence variants ranging from single base pair variants up to large structural rearrangements. Therefore, comprehensive sequence analysis of targeted loci is critical for the selection and QC of genetically modified cells and organisms.
In this webinar, Nicole will:
- Highlight the genetic characterization challenges for modified organisms and transgenic animals
- Explain why conventional technologies can be suboptimal when it comes to fully addressing those genetic QC needs
- Elaborate on how we routinely alleviate these genetic QC pains for our customers, by generating meaningful data on their samples and complex projects with our TLA-based solutions.
With almost a decade of experience, our unbiased and robust genetic QC testing method has been featured in over 70 peer-reviewed publications by both leading pharma/biotech (e.g. Genentech) as well as renowned academic research institutions (e.g. The Jackson Laboratory, Harvard University) globally. As such, our PhD-level experts have substantial experience analyzing a wide variety of modified organisms.
During this webinar, you can also expect to learn more about what is included our TLA (digital) reports, some of our newest add-on service offerings, and our newest membership in the NIST Genome Editing Consortium!
The webinar will be concluded with a Q&A.
Register today and don’t miss out on this insightful webinar, to learn why our unmatched genetic QC assays are considered as the gold-standard for the complete genetic characterization of transgene integration sites and targeted gene editing outcomes.
Your host:
Nicole Hendriks, BSc
International Sales Manager, Genetically Engineered Models
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